Efeito agudo do treinamento resistido sobre as expressões de irisina, PGC-1α e cardioproteção em roedores

Abstract

Irisin is a peptide discovered in 2012 with important functions on biological tissues homeostasis. The endocrine action was studied in adipose tissue, neurons and cardiac cells. However, there still a gap of knowledge about the exercise-induced irisin on cardioprotection of rodents. So, this study aims to investigate the acute effect of one session of resistance training on irisin levels and cardioprotection of rodents. For that, male wistar rats were submitted to 1 session of ladder resistance training and the cardioprotection were evaluated after 30 min of ischemia and 60 min of reperfusion on Langendorff. Irisin and PGC-1α was evaluated at skeletal muscle and cardiac tissue. The results demonstrated that 1 session of resistance training did not induce significative differences for LVDP, LVEDP, +dP/dt, -dP/dT and infarct size area, although the effect size for LVEDP is 0.81 indicating a large effect size. There is any significative different at irisin for skeletal muscle and cardiac tissue but effect size for cardiac irisin is 0.69, indicating a medium effect size. And for PGC-1α, there is a significative reduction at skeletal muscle. In conclusion, the results shown that immediately after a session of resistance training, there is no cardioprotection but from that session, the mechanisms which induce cardioprotection begin. And the levels of irisin did not alter on skeletal muscle and cardiac tissue immediately after a session of resistance training and the high intensity exercise induce a reduction of PGC-1α at skeletal muscle.