Síntese de 1,3,5-triazinas, potencialmente citotóxicas, pelo método de catálise por transferência de fase

Abstract

The substituted 1,3,5-triazines show very interesting properties as medicinal, anti-fungal, and polymerization agents, herbicides, cosmetics and more recently, they have been employed in H-bond interaction studies on biomolecules, for example DNA, and also as a stationary phase in HPLC. Based on these aspects, twelve 2-X, 4-Y. 6-Z-1,3,5-triazines were synthesized, where X=Y≠Z or X=Y=Z or X≠Y≠Z. x, Y and Z= chloro. 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl, propanoxy and propanethioxy. The full characterization of synthesized compounds was done by spectroscopic methods such as 1H, 13C NMR, infrared and GC-Mass. Phase Transfer Catalysis was employed and showed high yields when compared with traditional methodology. The s-triazine derivatives were analysed to verify cytotoxic activity against Brine Shrimp. The assymetric tri-substituted derivative has shown the strongest activity.