Estudo químico de Siolmatra brasiliensis (Cogn.) Baill - Cucurbitaceae

Abstract

Siolmatra brasiliensis, a climbing plant belonging to the Cucurbitaceae family is known popularly as “taiuá” or “cipó-tauá” and occurs generally in the central region of Brazil (Cerrado and Pantanal). Popularly, this plant is used as analgesic for toothache and its roots are considered a purifying agent, being used as anti-syphilis. The stalks are largely used for treatment of diabetes. The present work describes the isolation and structural elucidation of four triterpenoids from the hydroethanol extract – three cucurbitacins (cayaponosides A1, B4 and D) a dammarane saponin 3-O-β-D-gentiobiosyl-26-O-β-D-glucopyranosyl-20-hydroxydammar-24-ene, being described for the first time in the Plant Kingdom. The compounds were characterized by 1D and 2D NMR experiments, mass spectrometry and its absolute configurations were established for the first time by circular dichroism experiments.