Avaliação da influência do látex aquoso de Euphorbia milii var. hislopii (EUPHORBIACEAE) sobre o ciclo biológico de Schistosoma mansoni (TREMATODA, SCHISTOSOMATIDAE) em condições laboratoriais

Abstract

Schistosomiasis is one the most prevalent parasitic diseases in the world. With the problem of schistosomiasis infection control, the World Health Organization (WHO) has encouraged the development of strategies which aimed reducing / eliminating the Schistosoma mansoni in endemic areas. The aqueous solutions of latex from Euphorbia milii (syn. splendens) var. hislopii has showed relevant characteristics such as the selective product in the control of the disease on a large scale. The presence in the environment of evolutionary stages (eggs, miracidia and cercariae) and the pre-patent and patent periods in the intermediate host are critical stages in the cycle development, as in these periods such forms are more susceptible to the action of products administered in water. This study will be presented in article format and will be divided into three chapters, namely: 1 - Effect of molluscicide E. milii var. hislopii on the development of S. mansoni in Biomphalaria glabrata, 2 - Control of the dynamics of parasite S. mansoni in B. glabrata by exposure of eggs and miracidia with E. milii var. hislopii, and, 3-Influence of the latex of E. milii var. hislopii in the formation of S. mansoni in its definitive host. Based on the results, we conclude that the molluscicidal and schistosomicidal propertie of the product in question, enabled by the action of the product in infectious forms and in the intermediate hosts, promotes concomitantly and efficiently the control of transmission and morbidity of the disease. It is a unique product, being natural, biodegradable, low-dose, ecologically viable and altering the development of the parasite cycle in the definitive and intermediate hosts, leading to the reduction of infectious forms and the preservation of mollusc populations in their natural habitat.