Novos aspectos patológicos e patogenéticos da hematúria enzoótica bovina

Abstract

Ninety bovine bladders, from a slaughterhouse from the district of Barra Mansa/RJ and from bovine necropsies in Pteridium arachnoideum invaded locations, were examined when associated with clinical signs as those found in bovine enzootic hematuria. A diffuse wrinkling of the bladder mucosa was found in 40% of the cases which was correlated to increased mucous normal irregularity, polyp proliferation, lamina propria thickening, fibrose and, in severe cases, urotelial carcinoma multicentric proliferation of endophitic growth. Papillary tumours were microscopically classified as urotelial carcinoma in 35% of cases and papiloma in 65%. In some cases, carcinoma and adenocarcinoma presented less commom differentiation patterns as intestinal, of Paneth cells, and a mesonefroid adenocarcinoma in the trigone area, which demonstrated bladder embryological origin influence on different types of lesions that were found. Mucosal hemorrhagic lesions occurred in 100% of the cases and were associated with vascular proliferation and lamina propria hemorrhage or, in sever cases, 77,4% of hemorrhagic elevations were correlated to hemangioma or hemangiosarcoma. At last, we have established a correlation between P. arachnoideum chronic poisoning lesions and ionizing radiation bladder alteration in humans.