1. TEDE
  2. CAMPUS SEROPÉDICA
  3. Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)
  4. Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas)
???item.export.label??? ???item.export.type.endnote??? ???item.export.type.bibtex???

Please use this identifier to cite or link to this item: https://tede.ufrrj.br/jspui/handle/jspui/6576
Full metadata record
DC FieldValueLanguage
dc.creatorSantos, Bartolomeu Benedito Neves dos-
dc.creator.Latteshttp://lattes.cnpq.br/0596268295640239por
dc.contributor.advisor1França, Ticiana do Nascimento-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3545873525091315por
dc.contributor.advisor-co1Hassan, Claudia Esther Alicia Rocio-
dc.contributor.referee1França, Ticiana do Nascimento-
dc.contributor.referee2Nascimento, Aparecida Alves do-
dc.contributor.referee3Nogueira, Vivian de Assunção-
dc.contributor.referee4Driemeier, David-
dc.date.accessioned2023-05-08T18:09:44Z-
dc.date.issued2020-02-19-
dc.identifier.citationSANTOS, Bartolomeu Benedito Neves. Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães. 2020. 56 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.por
dc.identifier.urihttps://tede.ufrrj.br/jspui/handle/jspui/6576-
dc.description.resumoA literatura sobre plasmocitomas extramedulares caninos (PEMCs) é ampla e com informações divergentes. Devido sua grande variação morfológica, essa neoplasia é comumente confundida com outros tumores benignos e malignos na rotina de diagnóstico histopatológico; principalmente com o histiocitoma cutâneo canino (HCC), o sarcoma histiocítico canino (SHC) e o linfoma canino (LC). Com o objetivo de fornecer informações adicionais sobre a imunofenotipagem dos PEMCs, testes de imuno-histoquímica foram realizados em microarranjo de tecidos (TMA) com cores de 2mm, usando os marcadores convencionais CD79a (em duplicata), CD3 (em duplicata), MUM1 (em duplicata), Iba1 e cadeias leves λ e κ de imunoglobulina em amostras de 39 PEMCs, 27 HCCs e 8 LCs. Para fins de comparação e controle, o estudo também incluiu amostras de 2 SHCs, 2 mastocitomas cutâneos (MCC), 2 melanomas orais, 1 mieloma múltiplo e espécimes de linfonodo, baço, medula óssea e pele caninos. Além disso, foi feita uma investigação inédita com o anticorpo monoclonal antireceptor α da interleucina 3 (CD123) aplicado a cães. O CD123 tem sido amplamente estudado na medicina humana como eficiente marcador de algumas neoplasias linfoides, de mastócitos e de células dendríticas plasmocitoides blásticas, mas é praticamente inexplorado na medicina veterinária. Com o objetivo de avaliar a eficiência do microarranjo de tecidos (TMA) para alguns dos marcadores, realizou-se um estudo imuno-histoquímico piloto nas seções histológicas convencionais com MUM1 e CD79a em 27 amostras de PEMCs e 10 de HCCs, com os anticorpos anti-CD3 e CD79a em 8 amostras de LCs (5 cutâneos e 3 nodais) e com o anti-CD123 em amostras de 7 PEMCs e 2 HCCs. As conclusões mais importantes foram: 1) MUM1 é muito sensível (89,7%) para detectar PEMCs e eficiente para diferenciar os PEMCs de neoplasias histiocíticas. 2) Linfomas de células T podem expressar MUM1. 3) O CD123 é expresso por PEMCs, MCCs e SHCs, além de plasmócitos normais, endotélio e possivelmente por células dendríticas plasmocitoides caninas. 4) A expressão do antígeno CD123 em neoplasias malignas como MCC e SHC deve ser melhor investigada. 5) O anticorpo Iba1 teve 100% de sensibilidade para detectar HCCs e SHCs e, é muito específico para essas neoplasias.por
dc.description.abstractThe literature about canine extramedullary plasmacytoma (CEP) is wide and contradictory. Due its great morphological variety, this neoplasm is commonly confused with others benign and malignant tumors in histopathologic diagnostic routine; mainly with Canine Cutaneous Histiocytoma (CCH), Canine Histiocytic Sarcoma (CHS) and Canine Lymphoma (CL). Aiming to compile information to investigate and clarify aspects regarding the immunophenotyping of CEPs, immunohistochemistry tests were performed in tissue microarray (TMA) with 2mm colors, using the conventional markers CD79a (in duplicate), CD3 (in duplicate), MUM1 (in duplicate), Iba1 and immunoglobulin λ and κ light chains in 39 CEPs, 27 CCHs and 8 CLs. For comparison and control purposes, the study also included samples from 2 CHSs, 2 cutaneous mast cell tumors (MCT), 2 oral melanomas and 1 multiple myeloma; in addition to normal and reactive tissues from canine lymph nodes, spleen, bone marrow and skin. Furthermore, an analysis unprecedented was carried out with the antibody anti- Interleukin 3 alpha receptor (CD123) applied in dogs. The CD123 has been widely studied in human medicine as an efficient marker of some lymphoid neoplasms, mast cells and blastic plasmacytoid dendritic cells, but it is practically unexplored in medicine veterinary. To evaluate the efficiency of the tissue microarray (TMA) for some markers used, a pilot immunohistochemical study was carried out in the conventional histological sections with MUM1 and CD79a in 27 samples of CEPs and 10 of CCHs, with antibodies anti-CD3 and CD79a in 8 samples of CLs (5 cutaneous and 3 nodal) and with anti-CD123 in samples of 7 CEPs and 2 CCHs. The mainly conclusions found out were: 1) MUM1 is very sensitive (89.7%) to detect CEPs and efficient to differentiate CEPs from histiocytic neoplasms; 2) T-cell lymphomas can to express MUM1; 3) CD123 is expressed in CEPs, MCCs and CHSs, in addition to normal plasmocytes, endothelium and possibly by canine plasmacytoid dendritic cells; 4) CD123 antigen expressions in malignant neoplasms such as MCC and CHS must be further investigated; 5) The Iba1 antibody had 100% sensitivity to detect CCHs and CHSs, being very specific for these neoplasms.eng
dc.description.provenanceSubmitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2023-05-08T18:09:44Z No. of bitstreams: 1 2020 - Bartolomeu Benedito Neves dos Santos.Pdf: 3323153 bytes, checksum: 070ec8b5b6a0e81e7cf7324429ec2baa (MD5)eng
dc.description.provenanceMade available in DSpace on 2023-05-08T18:09:44Z (GMT). No. of bitstreams: 1 2020 - Bartolomeu Benedito Neves dos Santos.Pdf: 3323153 bytes, checksum: 070ec8b5b6a0e81e7cf7324429ec2baa (MD5) Previous issue date: 2020-02-19eng
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.formatapplication/pdf*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/73147/2020%20-%20Bartolomeu%20Benedito%20Neves%20dos%20Santos.Pdf.jpg*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.countryBrasilpor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesALCULUMBRE, S.; RAIELI, S.; HOFFMANN, C.; CHELBI, R.; DANLOS, F. X.; SOUMELIS, V. Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association. In: Seminars in Cell & Developmental Biology. Academic Press, 2019. p. 24-35 ARUN, S. S.; BREUER, W.; HERMANNS, W. Immunohistochemical examination of lightchain expression (λ/k ratio) in canine, feline, equine, bovine and porcine plasma cells. Journal of Veterinary Medicine Series A, v. 43, n. 1‐10, p. 573-576, 1996. ATHERTON, M. J.; VAZQUEZ‐SANMARTIN, S.; SHARPE, S.; WAUGH, E. M.; MORRIS, J. S. A metastatic secretory gastric plasmacytoma with aberrant CD3 expression in a dog. Veterinary Clinical Pathology, v. 46, n. 1, p. 520-525, 2017. BAER, K. E.; PATNAIK, A. K.; GILBERTSON, S. R.; HURVITZ, A. I. Cutaneous plasmacytomas in dogs: a morphologic and immunohistochemical study. Veterinary Pathology, v. 26, n. 3, p. 216-221, 1989. BARTL, R.; FRISCH, B.; FATEH-MOGHADAM, A.; KETTNER, G.; JAEGER, K.; SOMMERFELD, W. Histologic classification and staging of multiple myeloma: a retrospective and prospective study of 674 cases. American Journal of Clinical Pathology, v. 87, n. 3, p. 342-355, 1987. BOIOCCHI, L.; LONARDI, S.; VERMI, W.; FISOGNI, S.; FACCHETTI, F. BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells. Blood, v. 122, n. 2, p. 296-297, 2013. BOOSTROM, B. O.; MOORE, A. S.; DEREGIS, C. J.; ROBAT, C.; FREEMAN, K.; THAMM, D. H. Canine cutaneous plasmacytosis: 21 cases (2005-2015). Journal of Veterinary Internal Medicine, v. 31, n. 4, p. 1074–1080, 2017. BOSTOCK, D. E. Neoplasms of the skin and subcutaneous tissues in dogs and cats. British Veterinary Journal, v. 142, n. 1, p.1-19, 1986. BREUER, W.; COLBATZKY, F.; PLATZ, S.; HERMANNS, W. Immunoglobulin-producing tumours in dogs and cats. Journal of Comparative Pathology, v. 109, n. 3, p. 203-216, 1993. BREUER, W.; HERMANNS, W. Classification of lymphohaemopoietic neoplasias (LHN) in dogs and cats. European Journal of Veterinary Pathology, v. 4, p. 5-20, 1998. BRIZZI, M. F.; GARBARINO, G.; ROSSI, P. R.; PAGLIARDI, G. L.; ARDUINO, C.; AVANZI, G. C.; PEGORARO, L. Interleukin 3 stimulates proliferation and triggers endothelial-leukocyte adhesion molecule 1 gene activation of human endothelial cells. The Journal of Clinical Investigation, v. 91, n. 6, p. 2887-2892, 1993. BRUNNERT, S. R.; ALTMAN, N. H. Identification of immunoglobulin light chains in canine extramedullary plasmacytomas by thioflavine T and immunohistochemistry. Journal of Veterinary Diagnostic Investigation, v. 3, n. 3, p. 245-251, 1991. BUELENS, C.; BARTHOLOME, E. J.; AMRAOUI, Z.; BOUTRIAUX, M.; SALMON, I.; THIELEMANS, K.; WILLEMS, F.; GOLDMAN, M. Interleukin-3 and interferon β cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood, v. 99, n. 3, p. 993-998, 2002. BURNETT, R. C.; VERNAU, W.; MODIANO, J. F.; OLVER, C. S.; MOORE, P. F.; AVERY, A. C. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Veterinary Pathology, v. 40, n. 1, p. 32–41, 2003. CANGUL, I. T.; WIJNEN, M.; VAN GARDEREN, E.; VAN DEN INGH, T. S. G. A. M. Clinico‐pathological aspects of canine cutaneous and mucocutaneous plasmacytomas. Journal of Veterinary Medicine Series, v. 49, n. 6, p. 307-312, 2002. CLARK, G. N.; BERG, J.; ENGLER, S. J.; BRONSON, R. T. Extramedullary plasmacytomas in dogs: results of surgical excision in 131 cases. American Animal Hospital Association, v. 28, p. 105-111. 1992. CONROY, J. D. Canine skin tumors. Journal of the American Animal Hospital Association, v. 19, n.1, p. 91-114, 1983. CORCORAN, L.; FERRERO, I.; VREMEC, D.; LUCAS, K.; WAITHMAN, J.; O’KEEFFE, M.; SHORTMAN, K. The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells. The Journal of Immunology, v. 170, n. 10, p. 4926-4932, 2003. DAHL, C.; HOFFMANN, H. J.; SAITO, H.; SCHIØTZ, P. O. Human mast cells express receptors for IL‐3, IL‐5 and GM‐CSF; a partial map of receptors on human mast cells cultured in vitro. Allergy, v. 59, n. 10, p. 1087-1096, 2004. DAY, M. J. Immunophenotypic characterization of cutaneous lymphoid neoplasia in the dog and cat. Journal of Comparative Pathology, v. 112, n. 1, p. 79-96, 1995. DUNCAN, J. R.; PRASSE, K. W. Cytology of canine cutaneous round cell tumors: mast cell tumor, histiocytoma, lymphosarcoma and transmissible venereal tumor. Veterinary Pathology, v. 16, n. 6, p. 673–679, 1979. EHNINGER, A.; KRAMER, M.; RÖLLIG, C.; THIEDE, C.; BORNHÄUSER, M.; VON BONIN, M.; OELSCHLÄGEL, U. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia. Blood Cancer Journal, v. 4, n. 6, p. 218-e218, 2014. EHRENSING, G.; CRAIG, L. E.; Intravascular neoplastic cells in canine cutaneous plasmacytomas. Journal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 329–332, 2018. FANT, P.; CALDIN, M.; FURLANELLO, T.; DE LORENZI, D.; BERTOLINI, G.; BETTINI, G.; MASSERDOTTI, C. Primary gastric histiocytic sarcoma in a dog–a case report. Journal of Veterinary Medicine Series, v. 51, n. 7‐8, p. 358-362, 2004. FOOKSMAN, D. R.; SCHWICKERT, T. A.; VICTORA, G. D.; DUSTIN, M. L.; NUSSENZWEIG, M. C.; SKOKOS, D. Development and migration of plasma cells in the mouse lymph node. Immunity, v. 33, n.1, 118-127, 2010. FUKUMOTO, S.; HANAZONO, K.; KAWASAKI, N.; HORI, Y.; HIGUCHI, S.; SASAKI, T.; UCHIDE, T. Anaplastic atypical myeloma with extensive cutaneous involvement in a dog. Journal of Veterinary Medical Science, v. 74, n. 1, p. 111–115, 2012. FUNDERBURG, M. R. Adenocarcinoma subsequent to extramedullary myeloma in a German shepherd dog. Veterinary Medicine Small Animal Clinician, v. 72, p. 1185- 1188, 1977. GEISEL, O.; STIGLMAIR-HERB, M.; LINKE, R. P. Myeloma associated with immunoglobulin lambda-light chain derived amyloid in a dog. Veterinary Pathology, v. 27, n. 5, p. 374-376, 1990. GHADIALLY, F. N.; LOWES, N. R.; MESFIN, G. M. Atypical glycogen deposits in a plasmacytoma: an ultrastructural study. The Journal of Pathology, v. 122, n. 3, p. 157-162, 1977. GOLDSCHMIDT, M. H. Dermal mesenchymal neoplasms of domestic animals. In: Proc Annu Meet, Am Acad Vet Dermatol, p. 1-23. Orlando, 1985. GROSS, T. L.; IHRKE, P. J.; WALDER, E. J.; AFFOLTER, V. K. Plasmocitoma cutâneo. In: GROSS T. L. Doenças de pele do cão e gato: Diagnóstico Clínico e Histopatológico. 2ª ed. Oxford: Blackwell Science, 2005, p. 866 – 872. HARA, T.; MIYAJIMA, A. Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. Stem Cells, v. 14, p. 605– 618, 1996. HASSANEIN, N. M.; ALCANCIA, F.; PERKINSON, K. R.; BUCKLEY, P. J.; LAGOO, A. S. Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors (“hematogones”) and B lymphoblastic leukemia blasts. American Journal of Clinical Pathology, v. 132, n. 4, p. 573-580, 2009. HOENIG, M. Multiple myeloma associated with the heavy chains of immunoglobulin A in a dog. Journal of the American Veterinary Medical Association, v. 190, p. 1191-2, 1987. HOOD, L.; GRAY, W. R.; SANDERS, B. G.; DREYER, W. J. Light chain evolution. In: Cold Spring Harbor Symposia on Quantitative Biology. Cold Spring Harbor Laboratory Press, 1967. p. 133-146. HUANG, W.; XIE, J.; XU, X.; GAO, X.; XIE, P.; ZHOU, X. MUM-1 expression differentiates AITL with HRS-like cells from cHL. International Journal of Clinical and Experimental Pathology, v. 8, n. 9, p. 11372–11378, 2015. JEGO, G.; PALUCKA, A. K.; BLANCK, J. P.; CHALOUNI, C.; PASCUAL, V.; BANCHEREAU, J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity, v. 19, n. 2, p. 225-234, 2003. JONES, T. C.; HUNT, R. D. Veterinary Pathology, v. 5, p.41, 1983. KIUPEL, M.; WEBSTER, J. D.; BAILEY, K. L.; BEST, S.; DELAY, J.; DETRISAC, C. J.; HENDRICK, M. J. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Veterinary Pathology, v. 48, n. 1, 147-155, 2011. KREMER, M.; OTT, G.; NATHRATH, M.; SPECHT, K.; STECKER, K.; ALEXIOU, C.; QUINTANILLA-MARTINEZ, L.; FEND, F. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. The Journal of Pathology, v. 205, p. 92–101, 2005. KUPANOFF, P. A.; POPOVITCH, C. A.; GOLDSCHMIDT, M. H. Colorectal plasmacytomas: a retrospective study of nine dogs. Journal of the American Animal Hospital Association, v. 42, n. 1, p. 37-43, 2006. KURZROCK, R. Interleukin-3. In: KUFE, D. W.; POLLOCK, R. E.; WEICHSELBAUM R. R. (editors). Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker, 2003. KYRIAZIDOU, A.; BROWN, P. J.; LUCKE, V. M. An immunohistochemical study of canine extramedullary plasma cell tumors. Journal of Comparative Pathology, v.100, n. 3, p. 259– 266, 1989. LESTER, S. J.; MESFIN, G. M. A solitary plasmacytoma in a dog with progression to a disseminated myeloma. Canadian Veterinary Journal, v. 10, p. 284-286, 1980. LI, W.; YONG, J. L. Development of dendritic-cell lineages. Immunity, v. 26, n. 6, p. 741- 750, 2007. LUCKE, V. M. Primary cutaneous plasmacytomas in the dog and cat. Journal of Small Animal Practice, v. 28, n. 1, p. 49-55, 1987. MASON, D. Y.; CORDELL, J. L.; BROWN, M. H.; BORST, J.; JONES, M.; PULFORD, K.; JAFFE, E.; RALFKIAER, E.; DALLENBACH, F.; STEIN, H. CD79a: a novel marker for Bcell neoplasms in routinely processed tissue samples. Blood, v. 86, n. 4, p. 1453–1459, 1995. MAYER, M. N.; KERR, M. E.; GRIER, C. K.; MACDONALD, V. S. Immunoglobulin A multiple myeloma with cutaneous involvement in a dog. The Canadian Veterinary Journal, v. 49, n. 7, p. 694, 2008. MCCLELLAND, R. B. Myelocytoma in a dog. Journal of the American Veterinary Medical Association, p. 96, 1940. MCHALE, B.; BLAS-MACHADO, U.; OLIVEIRA, F. N.; RISSI, D. R. A divergent pseudoglandular configuration of cutaneous plasmacytoma in dogs. Journal of Veterinary Diagnostic Investigation, v. 30, n. 2, p. 260–262, 2018. MIKIEWICZ, M.; PAŹDZIOR-CZAPULA, K.; GESEK, M.; LEMISHEVSKYI, V.; OTROCKA-DOMAGAŁA, I. Canine and feline oral cavity tumours and tumour-like lesions: a retrospective study of 486 cases (2015–2017). Journal of Comparative Pathology, v. 172, p. 80-87, 2019. MILITI, S.; RICCIONI, R.; PAROLINI, I.; SPOSI, N. M.; SAMOGGIA, P.; PELOSI, E.; TESTA, U; PESCHLE, C. Expression of interleukin 3 and granulocyte–macrophage colony45 stimulating factor receptor common chain βc, βIT in normal haematopoiesis: lineage specificity and proliferation‐independent induction. British Journal of Haematology, v. 111, n. 2, p. 441- 451, 2000. MIYAJIMA, A.; MUI, A. L.; OGOROCHI, T.; SAKAMAKI, K. Receptors for granulocytemacrophage colony‐stimulating factor, interleukin‐3, and interleukin‐5. Blood, v. 82, p.1960– 1974, 1993. MONTES-MORENO, S.; RAMOS-MEDINA, R.; MARTÍNEZ-LÓPEZ, A.; CORNEJO, C. B.; CUBILLOS, A. P.; QUINTANA-TRUYENQUE, S.; PINILLA, S. M. R.; PAJARES, R.; SANCHEZ-VERDE, L.; MARTINEZ-TORRECUADRADA, J.; RONCADOR, G.; PIRIS, M. A. SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms. Blood, v. 121, n. 4, p. 643–647, 2013. MOORE, P. F. A review of histiocytic diseases of dogs and cats. Veterinary Pathology, v. 51, n. 1, p. 167-184, 2014. MOORE, P. F.; SCHRENZEL, M. D.; AFFOLTER, V. K.; OLIVRY, T.; NAYDAN, D. Canine cutaneous histiocytoma is an epidermotropic Langerhans cell histiocytosis that expresses CD1 and specific beta 2-integrin molecules. The American Journal of Pathology, v. 148, n. 5, p. 1699–1708, 1996. MORETTI, S.; LANZA, F.; DABUSTI, M.; TIEGHI, A.; CAMPIONI, D.; DOMINICI, M.; CASTOLDI, G. L. CD123 (interleukin 3 receptor alpha chain). Journal of Biological Regulators and Homeostatic Agents, v. 15, p. 98– 100, 2001. NATKUNAM, Y.; WARNKE, R. A.; MONTGOMERY, K.; FALINI, B.; RIJN, M. Analysis of MUM1/IRF4 protein expression using tissue microarrays and immunohistochemistry. Modern Pathology, v. 14, n. 7, p. 686-694, 2001. NICKOLOFF, B. J.; HILL, J.; WEISS, L.M. Canine neuroendocrine carcinoma. A tumor resembling histiocytoma. The American Journal of Dermatopathology, v. 7, n. 6, p. 579- 586, 1985. OLWEUS, J.; BITMANSOUR, A.; WARNIKE, R.; THOMPSON, P.; CARABALLIDO. J.; PICKER, L. J.; LUND-JOHANSEN, F. Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. Proceedings of the National Academy of Sciences, v. 94, n. 23, p. 12551- 12556, 1997. PARDANANI, A.; LASHO, T., CHEN, D.; KIMLINGER, T. K.; FINKE, C.; ZBLEWSKI, D.; BROOKS, C. Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells. Leukemia, v. 29, n. 7, p. 1605-1608, 2015. PAŹDZIOR-CZAPULA, K.; ROTKIEWICZ, T.; OTROCKA-DOMAGAŁA, I.; GESEK, M.; ŚMIECH, A. Morphology and immunophenotype of canine cutaneous histiocytic tumours with particular emphasis on diagnostic application. Veterinary Research Communications, v. 39, n. 1, p. 7-17, 2015. PELAYO, R.; HIROSE, J.; HUANG, J.; GARRETT, K. P.; DELOGU, A.; BUSSLINGER, M.; KINCADE, P. W. Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood, v. 105, n. 11, p. 4407-4415, 2005. PERLMANN, E.; DAGLI, M. L. Z.; MARTINS, M. C.; SIQUEIRA, S. A. C.; BARROS, P. S. M. Extramedullary plasmacytoma of the third eyelid gland in a dog. Veterinary Ophthalmology, v. 12, n. 1, p. 102-105, 2009. PLATZ, S. J.; BREUER, W.; PFLEGHAAR, S.; MINKUS, G.; HERMANNS, W. Prognostic value of histopathological grading in canine extramedullary plasmacytomas. Veterinary Pathology, v. 36, n. 1, p. 23-27, 1999. PLATZ, Stefan. Plasmozytome Bei Hund Und Katze. 1995. Tese de Doutorado. Ludwig- Maximilians-Universitat Munchen. RAKICH P. M.; LATIMER, K. S.; WEISS, R.; STEFFENS, W. L. Mucocutaneous plasmacytomas in dogs: 75 cases (1980-1987). Journal of the American Veterinary Medical Association, v. 194, n. 6, p. 803-810, 1989. RAMOS-VARA, J. A. Technical Aspects of Immunohistochemistry. Veterinary Pathology, v. 42, n. 4, p. 405–426, 2005. RAMOS-VARA, J. A.; MILLER, M. A.; PACE, L. W.; LINKE, R. P.; COMMON, R. S.; WATSON, G. L. Intestinal multinodular Aλ-amyloid deposition associated with extramedullary plasmacytoma in three dogs: Clinicopathological and immunohistochemical studies. Journal of Comparative Pathology, v. 119, n. 3, p. 239-249, 1998. RAMOS-VARA, J. A.; MILLER, M. A.; VALLI, V. E. O. Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Veterinary Pathology, v. 44, n. 6, p. 875-884, 2007. RAMOS-VARA, J. A.; TAKAHASHI, M.; ISHIHARA. T.; MILLER, M. A.; PACE, L. W.; CRAFT, D.; WATSON, G. L. Intestinal extramedullary plasmacytoma associated with amyloid deposition in three dogs: an ultrastructural and immunoelectron microscopic study. Ultrastructural Pathology, v. 22, n. 5, p. 393-400, 1998. RANNOU, B.; HÉLIE, P.; BÉDARD, C. Rectal Plasmacytoma with Intracellular Hemosiderin in a Dog. Veterinary Pathology, v. 46, n .6, p. 1181–1184, 2017. REGAN, R.C.; RASSNICK, K. M.; BALKMAN, C. E.; BAILEY, D. B. MCDONOUGH, S. P. Comparison of first‐opinion and second‐opinion histopathology from dogs and cats with cancer: 430 cases (2001–2008). Veterinary and Comparative Oncology, v. 8, p. 1-10, 2010. REIZIS, B. Plasmacytoid dendritic cells: development, regulation, and function. Immunity, v. 50. n. 1, p. 37–50, 2019. ROSOLEM, M. C.; VASCONCELOS, R. O.; GARRIDO, E.; CASTANHEIRA, T. L.; MOREIRA, P. R.; MAGALHÃES, G. M.; RAMOS, S. B. Immunodetection of myeloid and plasmacytoid dendritic cells in mammary carcinomas of female dogs. Pesquisa Veterinária Brasileira, v. 35, n. 11, p. 906-912, 2015. ROUT, E. D.; SHANK, A. M. M.; WAITE, A. H. K.; SIEGEL, A.; AVERY, A. C.; AVERY, P. R. Progression of cutaneous plasmacytoma to plasma cell leukemia in a dog. Veterinary Clinical Pathology, v. 46, n. 1, p. 77-84, 2017. ROWLAND, P. H.; LINKE, R. P. Immunohistochemical characterization of lambda lightchain- derived amyloid in one feline and five canine plasma cell tumors. Veterinary Pathology, v. 31, n. 3, p. 390-393, 1994. ROWLAND, P. H.; VALENTINE, B. A.; STEBBINS, K. E.; SMITH, C. A. Cutaneous plasmacytomas with amyloid in six dogs. Veterinary Pathology, v. 28, n. 2, p. 125-130, 1991. SALVA, K. A.; HAEMEL, A. K.; PINCUS, L. B.; LIU, J.; SUNDRAM, U.; GUITART, J.; WOOD, G. S. Expression of CD31/PECAM-1 (platelet endothelial cell adhesion molecule 1) by blastic plasmacytoid dendritic cell neoplasms. JAMA Dermatology, v. 150, n. 1, p.73-76, 2014. SCHOTTE, R.; NAGASAWA, M.; WEIJER, K.; SPITS, H.; BLOM, B. The ETS transcription factor spi-b is required for human plasmacytoid dendritic cell development. Journal of Experimental Medicine, v. 200, n. 11, p. 1503–1509, 2004. SCHRENZEL, M.D.; NAYDAN, D. K.; MOORE, P. F. Leukocyte differentiation antigens in canine cutaneous and oral plasmacytomas. Veterinary Dermatology, v. 9, p. 33-41, 1998. SEDLMEIER, H.; WEISS, E. Morphologisch-funktionelle Untersuchungen fiber das Plasmozytom des Hundes. Monatsheffle für Velerinärmedizin, v. 13, p. 245-251, 1958. SHIGEMATSU, H.; REIZIS, B.; IWASAKI, H.; MIZUNO, S. I.; HU, D.; TRAVER, D.; AKASHI, K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity, v. 21, n. 1, p. 43-53, 2004. SOUMELIS, V.; LIU, Y. J. From plasmacytoid to dendritic cell: Morphological and functional switches during plasmacytoid pre‐dendritic cell differentiation. European Journal of Immunology, v. 36, n.1, p. 2286-2292, 2006. STANNARD, A. A.; PULLEY, L. T. Tumors of the skin and soft tissues. In: Tumors in Domestic Animals, ed. Moulton, J. E, 2nd ed., p. 16-74. University of California Press, Berkeley, 1978. STILWELL, J. M.; RISSI, D. R. Immunohistochemical labeling of multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine cutaneous histiocytoma. Veterinary Pathology, v.55, n. 4, p. 517–520, 2018. SU, G. H.; CHEN, H. M.; MUTHUSAMY, N.; GARRETT-SINHA, L. A.; BAUNOCH, D.; TENEN, D. G.; SIMON, M. C. Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. The EMBO Journal, v. 16, n. 23, p. 7118–7129, 1997. TADMORI, W.; FEINGERSH, D.; CLARK, S. C.; CHOI, Y. S. Human recombinant IL-3 stimulates B cell differentiation. The Journal of Immunology, v. 142, n. 6, p. 1950-1955, 1989. TAKANOSU, M.; NAKANO, Y.; KAGAWA, Y. Improved clonality analysis based on immunoglobulin kappa locus for canine cutaneous plasmacytoma. Veterinary Immunology and Immunopathology, v. 215, p. 109903, 2019. TAKANOSU, M.; OKADA, K.; KAGAWA, Y. PCR-based clonality analysis of antigen receptor gene rearrangements in canine cutaneous plasmacytoma. The Veterinary Journal, v. 241, p. 31-37, 2018. TESTA, U.; FOSSATI, C.; SAMOGGIA, P.; MACSIULLI, R.; MARIANI, G.; HASSAN, J.; SPOSI, N. M.; GUERRIERO, R.; ROSATO, V.; GABBIANELLI, M.; PELOSI, E.; VALTIERI, M.; PESCHLE C. Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors. Blood, v. 88, n. 9, p. 3391–3406, 1996. TESTA, U.; PELOSI, E.; CASTELLI, G. CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies. Cancers, v. 11, n. 9, p. 1358, 2019. TESTA, U.; PELOSI, E.; FRANKEL, A. CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies. Biomarker Research, v. 2, n. 1, p. 4, 2014. TORRERO, M. N.; LARSON, D.; HÜBNER, M. P.; MITRE, E. CD200R surface expression as a marker of murine basophil activation. Clinical and Experimental Allergy, v. 39, n. 3, p. 361-369, 2009. UHLEN, M.; BANDROWSKI, A.; CARR, S.; EDWARDS, A.; ELLENBERG, J.; LUNDBERG, E.; YAMAMOTO, T. A proposal for validation of antibodies. Nature Methods, v. 13, n. 10, p. 823-827, 2016. VAIL, D. M. Hematopoietic tumors. Section D - plasma cell neoplasms. In: Small Animal Clinical Oncology. St. Louis: Saunders Elsevier, v. 4, p. 769–784, 2007. VAIL, D. M. Plasma cell neoplasms. In: Small Animal Clinical Oncology. Philadelphia: Saunders, p. 626-636, 2001. VAIL, D. M.; WITHROW, S. J. Tumors of the skin and subcutaneous tissues. In: WITHROW, S. J; MACEWEN’S, E. G. Small Clinical Veterinary Oncology. 5. ed. St Louis: Saunders Elsevier, 2007. Cap. 18, p. 375-401. VALLI, V. E.; MYINT, M. S.; BARTHEL, A.; BIENZLE, D.; CASWELL, J.; COLBATZKY, F.; KIUPEL, M. Classification of canine malignant lymphomas according to the World Health Organization criteria. Veterinary Pathology, v. 48, n. 1, p.198-211, 2011. WEISS, E. Morphologie und formale Genese der Neubildung der Zellen des retothelialen Systems (RS) bei Hund und Katze. Zentralblatt für Veterinärmedizin, v. 9, n. 5, p. 437-462, 1962. WEISS, E.; FRESE, K. International histological classification of tumours of domestic animals. VII. Tumours of the skin. Bulletin of the World Health Organization, v. 50, n. 1-2, p. 79- 100, 1974. XIA, X. L. L.; CHOI, Y. S. Human recombinant IL-3 is a growth factor for normal B cells. The Journal of Immunology, v. 148, n. 2, p. 491-497, 1992. YAGER J. A.; SCOTT D. W. The skin and appendages. In: JUBB K. V. F.; KENNEDY P. C.; PALMER N. Pathology of Domestic Animals. Vol.1. 4th ed. San Diego: Academic Press,. p. 531-738. 1993. YAGER, J. A.; SCOTT, D. W. Pathology of the Domestic Animals. 3th ed. v. 1. Eds KVF JUBB, P. C.; KENNEDY, P. C.; PALMER, N. 1985. YEARLEY, J. H.; STANTON, C.; OLIVRY, T.; DEAN, G. A. Phagocytic plasmacytoma in a dog. Veterinary Clinical Pathology, v. 36, n. 3, p. 293-296, 2007.por
dc.rightsAcesso Abertopor
dc.subjectPlasmocitoma caninopor
dc.subjectCélula dendrítica plasmocitoidepor
dc.subjectCD123por
dc.subjectCanine plasmacytomaeng
dc.subjectPlasmacytoid dendritic celleng
dc.subject.cnpqMedicina Veterináriapor
dc.titleImunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cãespor
dc.title.alternativeCompared immunophenotyping of extramedullary plasmacytomas, histiocytomas and cutaneous lymphomas in dogseng
dc.typeDissertaçãopor
Appears in Collections:Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas)

Files in This Item:
File Description SizeFormat 
2020 - Bartolomeu Benedito Neves dos Santos.Pdf3.25 MBAdobe PDFThumbnail

Download/Open Preview
Show simple item record Recommend this item


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.