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dc.creatorSantos, André Marandola dos-
dc.creator.Latteshttp://lattes.cnpq.br/1341170071765519por
dc.contributor.advisor1França, Ticiana do Nascimento-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3545873525091315por
dc.contributor.advisor-co1Peixoto, Paulo Vargas-
dc.contributor.advisor-co2Armién, Aníbal Guillermo-
dc.contributor.referee1Carvalho, Vivian de Assunção Nogueira-
dc.contributor.referee2Nascimento, Aparecida Alves do-
dc.contributor.referee3Helayel, Michel José Sales Abdalla-
dc.contributor.referee4Brust, Luis Armando Calvão-
dc.date.accessioned2021-03-31T02:14:22Z-
dc.date.issued2018-05-04-
dc.identifier.citationSantos, André Marandola dos. Doença do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiro. 2018. [73 f.]. Tese( Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas) - Universidade Federal Rural do Rio de Janeiro, [Seropédica - RJ] .por
dc.identifier.urihttps://tede.ufrrj.br/jspui/handle/jspui/4495-
dc.description.resumoDescreve-se um surto de doença do armazenamento lisossomal em ovinos induzida pelo consumo de Sida planicaulis no Estado do Rio de Janeiro. A ingestão de S. planicaulis Cav. (S. carpinifolia) é responsável pelo aparecimento desta enfermidade em bovinos, equinos, caprinos, ovinos e cervídeos cativos que ocorre, de forma natural, quando a planta predomina na pastagem e há baixa oferta de outras forragens. O principal composto tóxico desta planta, a swainsonina, inibe atividade enzimática de α-manosidase I e II que redunda no armazenamento de glicoproteínas no interior de lisossomos. Este acúmulo de substâncias promove compressão, deficiência no transporte intracitoplasmático e finalmente degeneração em diversos tecidos, dentre os quais o mais afetado é o nervoso. O exame físico dos animais afetados revelou déficit proprioceptivo, incoordenação motora, cambaleio à movimentação e tremores de intenção e na cabeça. Houve aumento acentuado dos tremores em cabeça e membros, com posterior dificuldade de se manter em estação e queda ao solo após a realização do “Head-Raising Test”. A histopatologia evidenciou severa distensão de neurônios de Purkinje, com aspecto espumoso e eventual cariólise ou cariopicnose e intensa vacuolização de células acinares do pâncreas e foliculares da tireoide. Adicionalmente, foram observadas vacuolizações em grandes corpos de neurônios com dissolução do citoplasma associada à marcada proliferação de astrócitos morfologicamente atípicos. Notou-se também múltiplos esferoides axonais de variados tamanhos. O exame lectino-histoquímico positivo para as lectinas Con A, WGA e sWGA foi capaz de caracterizar a enfermidade como uma glicoproteinose. A avaliação ultraestrutural evidenciou numerosos vacúolos de até 2,5μm de diâmetro, delimitados por membranas de até 20nm de espessura em células acinares do pâncreas. O diagnóstico da intoxicação por S. planicaulis foi estabelecido através dos dados epidemiológicos, achados clínico-patológicos e confirmados pelas avaliações lectino-histoquímica e ultraestrutural. A intoxicação natural por S. planicaulis em ovinos ainda não havia sido descrita no estado do Rio de Janeiro.por
dc.description.abstractThis paper describes an outbreak of lysosomal storage disease in sheep induced by Sida planicaulis in the state of Rio de Janeiro. The consumption of S. planicaulis is responsible for this disease in cattle, horses, goat, sheep and captive deer, which occurs naturally, when the plant is abundant and there is shortage of other forage. The main toxic compound in this plant, Swainsonine, inhibits α-manosidasis I e II enzymatic activitiy and causes glycoprotein storage in lysosomes. The storage provokes compression, deficiency in intracytoplasmatic transport, and finally, degenerative changes in various tissues, in which, nervous system is the most affected. Physical examination of the affected animals revealed proprioceptive déficit, motor incoordination, staggers and, neck and head intention tremors. ‘Head-Raising Test’ showed marked increase of head and limb tremors, with sequential difficulty in balance and tumble. Histopathology revealed severe distension of Purkinje cells, with foamy appearance, which eventually progressed to karyolysis and pyknosis, and intense vacuolization of pancreatic acinar and thyroid follicular cells. Additionally, there was vacuolization in neuronal bodies with dissolution of cytoplasm associated with marked proliferation of morphologically atypical astrocytes. Multiple axonal spheroids of variable sizes were noted. Positive reaction in lectin-histochemistry for lectins Con A, WGA, and sWGA was able to characterize the disease as a glycoproteinosis. Ultrastructural evaluation of pancreas sections evidenced numerous vacuoles up to 2,5μm in diameter, circled by 20nm wide membranes in acinar cells. In the present report, diagnosis of S. planicaulis toxicosis was established by epidemiological data, clinical and pathological findings, and confirmed by lectin-histochemistry and ultrastructural evaluation. Natural toxicosis in sheep by Sida planicaulis has not yet been described in the state of Rio de Janeiro.eng
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dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil.por
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dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.countryBrasilpor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesABREU, S.; HAYDEN, J.; BERTHOLD, P.; SHAPIRO, I. M.; DECKER, S.; PATTERSON, D.; HASKINS, M.; Growth plate pathology in feline mucopolysaccharidosis VI. Calcified Tissue International, v. 57, n. 3, p. 185-190, 1995. ALROY, J. ORGAD, U.; UCCI, A. A.; PEREIRA, M. E. Identification of glycoprotein storage diseases by lectins: a new diagnostic method. Journal of Histochemistry & Cytochemistry, v. 32, n. 12, p. 1280-1284, 1984. ALROY, J.; ORGAD, U.; UCCI, A. A.; GAVRIS, V. E. Swainsonine toxicosis mimics lectin histochemistry of mannosidosis. Veterinary Pathology, v. 22, n. 4, p. 311-316, 1985. ALROY, J.; UCCI, A. A.; WARREN, C. D. Human and canine fucosidosis: a comparative lectin histochemistry study. Acta Neuropathologica, v. 67, n. 3, p. 265-271, 1985. ALROY, J.; UCCI, A. A.; GOYAL, V; WOODS, W. Lectin histochemistry of glycolipid storage diseases on frozen and paraffin-embedded tissue sections. Journal of Histochemistry & Cytochemistry, v. 34, n. 4, p. 501-505, 1986. ALROY, J.; GOYAL, V.; SKUTELSKY, E. Lectin histochemistry of mammalian endothelium. Histochemistry and Cell Biology, v. 86, n. 6, p. 603-607, 1987. ANJOS, B. L.; PEIXOTO, P. V.; CALDAS, S. A.; BALTHAZAR, D.; FRANÇA, T. N.; ARMIÉN, A. G. et al. Poisoning by the swainsonine-containing plant Sida carpinifolia in captive sambar deer (Cervus unicolor). Journal of Zoo and Wildlife Medicine, v. 47, n. 3, p. 862-867, 2016. ANNUNZIATA, I.; D’AZZO, A. Galactosialidosis: historic aspects and overview of investigated and emerging treatment options. Expert Opinion on Orphan Drugs, v. 5, n. 2, p. 131-141, 2017. ARMIÉN, A. G.; TOKARNIA, C. H.; PEIXOTO, P. V.; FRESE K. Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp. fistulosa (Convolvulaceae). Veterinary Pathology, v. 44, n. 2, p. 170-184, 2007. ARMIÉN, A. G.; TOKARNIA, C. H.; PEIXOTO, P. V.; BARBOSA, J. D.; FRESE K. Clinical and morphologic changes in ewes and fetuses poisoned by Ipomoea carnea subspecies fistulosa. Journal of veterinary diagnostic investigation, v. 23, n. 2, p. 221-232, 2011. ARAÚJO, J. A. S.; RIET-CORREA, F.; MEDEIROS, R. M. T.; SOARES, M. P.; OLIVEIRA, D. M.; CARVALHO, F. K. L. Intoxicação experimental por Ipomoea asarifolia (Convolvulaceae) em caprinos e ovinos. Pesquisa Veterinária Brasileira, v. 28, n. 10, p. 488-494, 2008. 61 BARBOSA, J. D.; OLIVEIRA, C. M. C.; DUARTE, M. D.; PEIXOTO, P. V.; TOKARNIA, C. H. Intoxicações experimental e natural por Ipomoea asarifolia (Convolvulaceae) em búfalos e outros ruminantes. Pesquisa Veterinária Brasileira, v. 25, n. 4, p. 231-234, 2005. BARBOSA, R. C. RIET-CORREA, F.; MEDEIROS, R. M. T.; LIMA, E. F.; BARROS, S. S.; GIMENO, E. J.; MOLYNEUX, R. J.; GARDNER, D. R. Intoxication by Ipomoea sericophylla and Ipomoea riedelii in goats in the state of Paraíba, Northeastern Brazil. Toxicon, v. 47, n. 4, p. 371-379, 2006. BARTON, N. W.; BRADY, R. O.; DAMBROSIA, J. M.; BISCEGLIE, A. M.; DOPPELT, S. H.; FILL, S. C.; MANKIN, H. J.; MURRAY, G. J.; PARKER, R. I.; ARGOFF, C. E.; GREWALL, R. P.; YU, K. Replacement therapy for inherited enzyme deficiency—macrophage-targeted glucocerebrosidase for Gaucher's disease. New England Journal of Medicine, v. 324, n. 21, p. 1464-1470, 1991. BASSUINO, D. M.; KONRADT, G; BIANCHI, M. V.; REIS, M. O.; PAVARINI, S.; DRIEMEIER, D. Spontaneous poisoning by Sida carpinifolia (Malvaceae) in horses. Pesquisa Veterinária Brasileira, v. 37, n. 9, p. 926-930, 2017 BEARD, H; HASSIOTIS, S.; GAI, W. P.; PARKINSON-LAWRENCE, E.; HOPWOOD, J. J.; HEMSLEY, K. M. Axonal dystrophy in the brain of mice with Sanfilippo syndrome. Experimental Neurology, 2017. BEDIN, M.; COLODEL, E. M.; GIUGLIANI, R.; ZLOTOWSKY, P.; CRUZ, C. E. F.; DRIEMEIER, D. Urinary oligosaccharides: A peripheral marker for Sida carpinifolia exposure or poisoning. Toxicon, v. 53, n. 5, p. 591-594, 2009. BEDIN, M.; COLODEL, E. M.; VIAPIANA, M.; MATTE, U.; DRIEMEIER, D; GIUGLIANI, R. Alpha-mannosidase activity in goats fed with Sida carpinifolia. Experimental and Toxicologic Pathology, v. 62, n. 2, p. 191-195, 2010. BEZERRA JÚNIOR, P.S.; RAYMUNDO, D.L.; SPANANBERG, A.; CORRÊA, A.M.R.; BANGEL JÚNIOR, J.J.; FERREIRO, L.; DRIEMEIER, D. Neurotoxicose em bovinos associada ao consumo de bagaço de malte contaminado por Aspergillus clavatus. Pesquisa Veterinária Brasileira, v. 29, n. 3, p. 220-228, 2009. BHAUMIK, M.; MULLER, V. J.; ROZAKLIS, T.; LINDA, J.; DOBRENIS, K.; BHATTACHARYYA, R.; STANLEY, P. A mouse model for mucopolysaccharidosis type III A (Sanfilippo syndrome). Glycobiology, v. 9, n. 12, p. 1389-1396, 1999. BIRKENMEIER, E. H.; DAVISSON, M. T.; BEAMER, W. G.; GANSCHOW, R. E.; VOGLER, C. A.; GWYNN, B.; WAWRZYNIAK, C. J. Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency. Journal of Clinical Investigation, v. 83, n. 4, p. 1258, 1989. BLEY, A. E.; GIANNIKOPOULOS, O. A.; HAYDEN, D.; KUBILLUS, K.; TIFFT, C. J.; EICHLER, F. S. Natural history of infantile GM2 gangliosidosis. Pediatrics, v. 128, n. 5, p. e1233-e1241, 2011. 62 BORGES, A. S.; OLIVEIRA-FILHO, J. P.; SIMON, J. J.; PALUMBO, M. I. P.; IMERMAN, P. M. Slaframine toxicosis in Brazilian horses causing excessive salivation. Equine Veterinary Education, v. 24, n. 6, p. 279-283, 2012. BOURKE, C. A. The clinical differentiation of nervous and muscular locomotor disorders of sheep in Australia. Australian Veterinary Journal, v. 72, n. 6, p. 228-234, 1995. BOVINI, M. G. Sida in Lista de Espécies da Flora do Brasil. Jardim Botânico do Rio de Janeiro. 2015. Disponível em: <http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB9227>. Acesso em 02 de Abril de 2018. BURDITT, L. J.; CHOTAI, K.; HIRANI, S.; NUGENT, P. G.; WINCHESTER, P. G.; BLAKEMORE, W. F. Biochemical studies on a case of feline mannosidosis. Biochemical Journal, v. 189, n. 3, p. 467-473, 1980. CALLAHAN, J. W. Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure–function studies of lysosomal β-galactosidase and the non-lysosomal β-galactosidase-like protein. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1455, n. 2, p. 85-103, 1999. CANTÓN, G.; CAMPERO, C.; VILLA, M.; ODRIOZOLA, E. Acute and chronic nervous signs in cattle associated with Phalaris angusta poisoning in Argentina. Pesquisa Veterinária Brasileira, v. 30, n. 1, p. 63-66, 2010. CAWDELL‐SMITH, A. J.; SCRIVENER, C. J.; BRYDEN, W. L. Staggers in horses grazing paspalum infected with Claviceps paspali. Australian Veterinary Journal, v. 88, n. 10, p. 393-395, 2010. CHOLICH, L. A.; MÁRQUEZ, M.; BATLLE, M. P.; GIMENO, E. J.; TEIBLER, G. P.; RIOS, E. E.; ACOSTA, A. C. Experimental intoxication of guinea pigs with Ipomoea carnea: Behavioural and neuropathological alterations. Toxicon, v. 76, p. 28-36, 2013. CIANCIOLO, R. E.; RHODES, J. L.; HASKINS, M. E.; CLUBB, F. J.; LEES, G. E. Renal failure associated with mucopolysaccharidosis type I in a cat from a MPS I research colony. Comparative Medicine, v. 61, n. 5, p. 441-444, 2011. COLODEL, E. M.; GARDNER, D. R.; ZLOTOWSKY, P.; DRIEMEIER, D. Identification of swainsonine as a glycoside inhibitor responsible for Sida carpinifolia poisoning. Veterinary and Human Toxicology, v. 44, n. 3, p. 177-178, 2002a. COLODEL, E. M.; DRIEMEIER, D.; LORETTI, A. P.; GIMENO, E. J.; TRAVERSO, S. D.; SEITZ, A. L.; ZLOTOWSKY, P. Aspectos clínicos e patológicos da intoxicação por Sida carpinifolia (Malvaceae) em caprinos no Rio Grande do Sul. Pesquisa Veterinária Brasileira, v. 22, n. 2, p. 51-57, 2002b. COOK, D.; GARDNER, D. R.; PFISTER, J. A. Swainsonine-containing plants and their relationship to endophytic fungi. Journal of Agricultural and Food Chemistry, v. 62, n. 30, p. 7326-7334, 2014. 63 COOK, D.; OLIVEIRA, C. A.; GARDNER, D. R.; PFISTER, J. A.; RIET-CORREA, G.; RIET-CORREA, F. Changes in swainsonine, calystegine, and nitrogen concentrations on an annual basis in Ipomoea carnea. Toxicon, v. 95, p. 62-66, 2015. CORK, L. C.; MUNNELL, J. F.; LORENZ, M. D. The pathology of feline GM2 gangliosidosis. The American Journal of Pathology, v. 90, n. 3, p. 723, 1978. DANTAS, A. F. M.; RIET-CORREA, F.; GARDNER, D. R.; MEDEIROS, R. M. T.; BARROS, S. S.; ANJOS, B. L.; LUCENA, R. B. Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Turbina cordata in Northeastern Brazil. Toxicon, v. 49, n. 1, p. 111-116, 2007. DE LAHUNTA, A.; GLASS, E. N. Veterinary Neuroanatomy and Clinical Neurology. 3ª ed. Elsevier Health Sciences, 540p, 2009. DESNICK, R. J.; BRADY, R.; BARRANGER, J.; COLLINS, A. J.; GERMAIN, D. P.; GOLDMAN, M.; GRABOWSKY, G.; PACKMAN, S.; WILLCOX, W. R. Fabry disease, an under-recognized multisystemic disorder: expert recommendations for diagnosis, management, and enzyme replacement therapy. Annals of Internal Medicine, v. 138, n. 4, p. 338-346, 2003. DOMBROWSKI, D. C. S.; CARMICHAEL, K. P.; WANG, P.; O'MALLEY, T. M.; HASKINS, M. E.; GIGER, U. Mucopolysaccharidosis type VII in a German shepherd dog. Journal of the American Veterinary Medical Association, v. 224, n. 4, p. 553-557, 2004. DONNELLY, W. J. C.; SHEAHAN, B. J.; ROGERS, T. A. GM1 gangliosidosis in Friesian calves. The Journal of Pathology, v. 111, n. 3, p. 173-179, 1973. DORLING, P. R.; HUXTABLE, C. R.; VOGEL, P. Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis. Neuropathology and Applied Neurobiology, v. 4, n. 4, p. 285-295, 1978. DORLING, P. R.; HUXTABLE, C. R.; COLEGATE, S. M. Inhibition of lysosomal α-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochemical Journal, v. 191, n. 2, p. 649-651, 1980. DRIEMEIER, D.; COLODEL, E. M.; GIMENO, E. J.; BARROS, S. S. Lysosomal storage disease caused by Sida carpinifolia poisoning in goats. Veterinary Pathology, v. 37, n. 2, p. 153-159, 2000. ELLINWOOD, N. M.; WANG, P.; SKEEN, T.; SHARP, N. J. H.; CESTA, M.; DECKER, S.; HARDAM, E. A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-α-D-glucosaminidase deficiency in Schipperke dogs. Journal of Inherited Metabolic Disease, v. 26, n. 5, p. 489-504, 2003. EMBURY, D. H.; JERRETT, I. V. Mannosidosis in Galloway calves. Veterinary Pathology, v. 22, n. 6, p. 548-551, 1985. 64 EZAKI, J.; WOLFE, L. S.; KOMINAMI, E. Molecular basis of lysosomal accumulation of subunit c of mitochondrial ATP synthase in neuronal ceroid-lipofuscinosis. Journal of Inherited Metabolic Disease, v. 16, n. 2, p. 296-298, 1993. FEITOSA, F. L. F. Semiologia Veterinária: A Arte Do Diagnóstico. Grupo Gen-Editora Roca Ltda., 2000. FISHER, R. A.; RATHKE, J. S.; KELLEY, J. A.; DUNSTAN, R. W.; CAVANAGH, K.; JONES, M. Z. Inheritance of β‐mannosidosis in goats. Animal Genetics, v. 17, n. 4, p. 183-190, 1986. FLETCHER, J. L.; WILLIAMSON, P.; HORAN, D.; TAYLOR, R. M. Clinical signs and neuropathologic abnormalities in working Australian Kelpies with globoid cell leukodystrophy (Krabbe disease). Journal of the American Veterinary Medical Association, v. 237, n. 6, p. 682-688, 2010. FLETCHER, J. L.; TAYLOR, R. M. Associations between neurologic dysfunction and lesions in canine fucosidosis. Genes, Brain and Behavior, v. 15, n. 4, p. 420-428, 2016. FONTEQUE, J. H.; SOUZA, A. F.; SCHADE, J.; MULLER T. R.; WEINERT, N. C. Slaframine intoxication in horse in Santa Catarina state. Veterinaria e Zootecnia, v. 22, n. 3, p. 375-379, 2015. FURLAN, F. H.; LUCIOLI, J.; VERONEZI, L. O.; TRAVERSO, S. D.; GAVA, A.. Intoxicação experimental por Sida carpinifolia (Malvaceae) em bovinos. Pesquisa Veterinária Brasileira, v. 28, n. 1, p. 57-62, 2008. FRAMPTON, J. E. Sebelipase Alfa: A Review in Lysosomal Acid Lipase Deficiency. American Journal of Cardiovascular Drugs, v. 16, n. 6, p. 461-468, 2016. FURLAN, F. H.; LUCIOLI, J.; VERONEZI, L. O.; MEDEIROS, A. L.; BARROS, S. S., TRAVERSO, S. D.; GAVA, A. Spontaneous lysosomal storage disease caused by Sida carpinifolia (Malvaceae) poisoning in cattle. Veterinary Pathology, v. 46, n. 2, p. 343-347, 2009. GAVA, A. SOUSA, R. S; DEUS, M. S. D.; PILATI, C.; CRISTANI, J.; MORI, A.; NEVES, D. S. Phalaris angusta (Gramineae) causing neurological disease in cattle in the State of Santa Catarina, Brazil. Pesquisa Veterinária Brasileira, v. 19, n. 1, p. 35-38, 1999. GIESELMANN, V. Lysosomal storage diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, v. 1270, n. 2-3, p. 103-136, 1995. GITZELMANN, R.; BOSSHARD, N. U.; SUPERTI-FURGA, A.; SPYCHER, M. A.; BRINER, J.; WIESMANN, U.; LITSCHI, B.. Feline mucopolysaccharidosis VII due to β-glucuronidase deficiency. Veterinary Pathology, v. 31, n. 4, p. 435-443, 1994. GODOY, G. S.; CASTRO NETTO, A.; MOMO, C.; DUNE, A. C.; ÁVILA, L. G.; ALESSI, A. C.; MARQUES, L. C.; CASTRO, M. B. Intoxicação natural por Sida carpinifolia (Malvaceae) em caprinos no estado de São Paulo. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 57, supl.1, n.25. 2005 65 GOLDMANN, A.; MESSAGE, B.; TEPFER, D.; MOLYNEUX, R. J.; DUCLOS O.; BOYER F. D.; PAN Y. T.; ELBEIN, A. D. Biological Activities of the Nortropane Alkaloid, Calystegine B2, and Analogs: Structure-Function Relationships. Journal of natural products, v. 59, n. 12, p. 1137-1142, 1996. GOLDSTEIN, I. J.; HUGHES, R. C.; MONSIGNY, M.; OSAWA, T.; SHARON, N. What should be called a lectin? Nature, v. 285, n. 5760, p. 66-66, 1980. GUARANÁ, E. L. S.; RIET-CORREA, F.; MENDONÇA, C. L.; MEDEIROS, R. M. T.; COSTA, N. A.; AFONSO, J. A. B. Poisoning by Solanum paniculatum (Solanaceae) in cattle. Pesquisa Veterinária Brasileira, v. 31, n. 1, p. 59-64, 2011. HARAGUCHI, M.; GORNIAK, S. L.; IKEDA, K.; MINAMI, Y.; KATO, A.; WATSON, A. A.; NASH, R. J.; MULYNEUX, R. J.; ASANO, N. Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae). Journal of Agricultural and Food Chemistry, v. 51, n. 17, p. 4995-5000, 2003. HARRIS, C. M.; CAMPBELL, B. C.; MOLLYNEUX, R. J.; HARRIS, T. M. Biosynthesis of swainsonine in the diablo locoweed (Astragalus oxyphyrus). Tetrahedron Letters, v. 29, n. 38, p. 4815-4818, 1988. HASKINS, M. E.; AGUIRRE, G. D.; JEZYK, P. F.; PATTERSON, D. F. The pathology of the feline model of mucopolysaccharidosis VI. The American Journal of Pathology, v. 101, n. 3, p. 657, 1980. HASKINS, M. E.; AGUIRRE, G. D.; JESYK, P. F.; DESNICK, R. J.; PATTERSON, D. F. The pathology of the feline model of mucopolysaccharidosis I. The American Journal of Pathology, v. 112, n. 1, p. 27, 1983. HASKINS, M. E; DESNICK, R. J.; DIFERRANTE, N.; JEZYK, P. F.; PATTERSON, D. F. β-glucuronidase deficiency in a dog: a model of human mucopolysaccharidosis VII. Pediatric Research, v. 18, n. 10, p. 980-984, 1984. HASKINS, M.; CASAL, M.; ELINWOOD, N. M.; MELNICZEK, J.; MAZRIER, H.; GIGER, U. Animal models for mucopolysaccharidoses and their clinical relevance. Acta Paediatrica, v. 91, n. s439, p. 88-97, 2002. HEALY, P. J.; BABIDGE, P. J.; EMBURY, D. H.; HARRISON, M. A.; JUDSON, G. J.; MASON, R. W.; PETTERSON, D. S.; SINCLAIR, A. J. Control of α‐mannosidosis in Angus cattle. Australian Veterinary Journal, v. 60, n. 5, p. 135-137, 1983. HEALY, P. J.; MALMO, J. Roles for biochemical and poly‐merase chain reaction technolo gies in diagnosis and control of bovine a‐mannosidosis. Australian Veterinary Journal, v. 76, n. 10, p. 699-700, 1998. HERS, H. G. α-Glucosidase deficiency in generalized glycogen-storage disease (Pompe's disease). Biochemical Journal, v. 86, n. 1, p. 11, 1963. HUANG, Y.; LI, W.; ZHAO, X; DING, L.; YU, G.; DONG, F; DU, Q.; XU, X; TONG, D. Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology, v. 80, n. 1, p. 41-49, 2013. 66 HUXTABLE, C. R.; CHAPMAN, H. M.; MAIN, D. C.; VASS, D.; PEARSE, B. H. G.; HILBERT, B. J. Neurological disease and lipofuscinosis in horses and sheep grazing Trachyandra divarikata (branched onion weed) in south Western Australia. Australian Veterinary Journal, v. 64, n. 4, p. 105-108, 1987. JAMES, L. F. Effect of locoweed (Astragalus lentiginosus) feeding of fetal lamb development. Canadian Journal of Comparative Medicine, v. 40, n. 4, p. 380, 1976. JEZYK, P. F.; HASKINS, M. E.; PATTERSON, D. F.; MELLMAN, W. J.; GREENSTEIN, M. Mucopolysaccharidosis in a cat with arylsulfatase B deficiency: a model of Maroteaux-Lamy syndrome. Science, v. 198, n. 4319, p. 834-836, 1977. JOLLY, R. D.; THOMPSON, K. G. The pathology of bovine mannosidosis. Veterinary Pathology, v. 15, n. 2, p. 141-152, 1978. JOLLY, R. D.; WALKLEY, S. U. Lysosomal storage diseases of animals: an essay in comparative pathology. Veterinary Pathology, v. 34, n. 6, p. 527-548, 1997. JONES, M. Z.; DAWSON, G. Caprine beta-mannosidosis. Inherited deficiency of beta-D-mannosidase. Journal of Biological Chemistry, v. 256, n. 10, p. 5185-5188, 1981. JONES, M. Z.; CUNNINGHAM, J. G.; DADE, A. W.; ALESSI, D. M.; MOSTOSKY, U. V.; VORRO, J. R.; BENITEZ, J. T.; LOVELL, K. L. Caprine β-mannosidosis: clinical and pathological features. Journal of Neuropathology & Experimental Neurology, v. 42, n. 3, p. 268-285, 1983. JONES, M. Z.; ALROY, J.; DOWNS-KELLY, E.; LUCAS, R. E.; KRAEMER, S. A.; CAVANAGH, K. T.; KING, B. HOPWOOD, J. J. Caprine mucopolysaccharidosis IIID. Journal of Molecular Neuroscience, v. 24, n. 2, p. 277-291, 2004. KAGAN, I. A. Blackpatch of Clover, Cause of Slobbers Syndrome: A Review of the Disease and the Pathogen, Rhizoctonia leguminicola. Frontiers in Veterinary Science, v. 3, 2016. KELLERMAN, T. S. COETZER, J. A. W.; NAUDÉ, T. W.; BOTHA, C. J. Plant poisonings and mycotoxicoses of livestock in Southern Africa. Oxford University Press Southern Africa, 2005. KELLY, W. R.; CLAGUE, A. E.; BARNS, R. J.; BATE, M. J.; MACKAY, B. M. Canine α-L-fucosidosis: a storage disease of Springer Spaniels. Acta Neuropathologica, v. 60, n. 1, p. 9-13, 1983. KNOWLES, K. ALROY, J.; CASTAGNARO, M.; RAGHAVAN, S. S.; JAKOWSKY, R. M.; FREDEN, G. O. Adult-onset lysosomal storage disease in a Schipperke dog: clinical, morphological and biochemical studies. Acta Neuropathologica, v. 86, n. 3, p. 306-312, 1993. KOHYAMA, M.; YABUKI, A.; OCHIAI, K.; NAKAMOTO, Y.; UCHIDA, K.; HASEGAWA, D.; TAKAHASHI, K.; KAWAGUCHI, H.; TSUBOI, M.; YAMATO, O. In situ detection of GM1 and GM2 gangliosides using immunohistochemical and 67 immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. BMC Veterinary Research, v. 12, n. 1, p. 67, 2016. KONDAGARI, G. S.; KING, B. M.; THOMSON, P. C.; WILLIAMSON, P.; CLEMENTS, P. R.; FULLER, M.; HEMSLEY, K. M.; HOPWOOD, J. J.; TAYLOR, R. M. Treatment of canine fucosidosis by intracisternal enzyme infusion. Experimental Neurology, v. 230, n. 2, p. 218-226, 2011. LAWSON, C. A.; MARTIN, D. R. Animal models of GM2 gangliosidosis: utility and limitations. The Application of Clinical Genetics, v. 9, p. 111, 2016. LI, Q.; WANG, Y.; MOLDZIO, R.; LIN, W.; RAUSCH, W. Swainsonine as a lysosomal toxin affects dopaminergic neurons. Journal of Neural Transmission, v. 119, n. 12, p. 1483-1490, 2012. LIMA, E. F.; RIET-CORREA, F.; MEDEIROS, R. M. T. Spontaneous poisoning by Solanum subinerme Jack as a cause of cerebellar cortical degeneration in cattle. Toxicon, v. 82, p. 93-96, 2014. LORETTI, A. P.; COLODEL, E. M.; DRIEMEIER, D; CORRÊA, A. M.; BANGEL Jr, J. J.; FERREIRO, L. Neurological disorder in dairy cattle associated with consumption of beer residues contaminated with Aspergillus clavatus. Journal of Veterinary Diagnostic Investigation, v. 15, n. 2, p. 123-132, 2003. LOVELL, K. L.; JONES, M. Z. Axonal and myelin lesions in β-mannosidosis: Ultrastructural characteristics. Acta Neuropathologica, v. 65, n. 3, p. 293-299, 1985. MACKENZIE, C. D.; JOHNSON, R. P. Lafora's disease in a dog. Australian Veterinary Journal, v. 52, n. 3, p. 144, 1976. MAIN, D. C.; SLATTER, D. H.; HUXTABLE, C. R.; CONSTABLE, I. C.; DORLING, P. R. Stypandra imbricata (“blindgrass”) toxicosis in goats and sheep—clinical and pathologic findings in 4 field cases. Australian Veterinary Journal, v. 57, n. 3, p. 132-135, 1981. MARKELLO, T. C.; BERNARDINI, I. M.; GAHL, W. A. Improved renal function in children with cystinosis treated with cysteamine. New England Journal of Medicine, v. 328, n. 16, p. 1157-1162, 1993. MARSH, C. D. The loco-weed disease of the plains. US Department of Agriculture, Bureau of Animal Industry, 1909. MATHEWS, F. P. Locoism in domestic animals. Texas FARMER Collection, 1932. MEDEIROS, R. M. T.; BARBOSA, R. C.; RIET-CORREA, F.; LIMA, E. F.; TABOSA, I. M.; BARROS, S. S.; GARDNER, D. R.; MOLYNEUX, R. J. Tremorgenic syndrome in goats caused by Ipomoea asarifolia in Northeastern Brazil. Toxicon, v. 41, n. 7, p. 933-935, 2003. MENDONÇA, F. S.; ALBUQUERQUE, R. F.; EVÊNCIO-NETO, J.; FREITAS, S. H.; DÓRIA, R. G. S.; BOABAID, F. M.; DRIEMEIER, D.; GARDNER, D. R.; RIET- 68 CORREA, F.; COLODEL, E. M. Alpha-mannosidosis in goats caused by the swainsonine-containing plant Ipomoea verbascoidea. Journal of Veterinary Diagnostic Investigation, v. 24, n. 1, p. 90-95, 2012. MURNANE, R. D.; HARTLEY, W. J.; PRIEUR, D. J. Similarity of lectin histochemistry of a lysosomal storage disease in a New Zealand lamb to that of ovine GM1 gangliosidosis. Veterinary Pathology, v. 28, n. 4, p. 332-335, 1991. NICAISE, A. M.; BONGARZONE, E. R.; CROCKER, S. J. A microglial hypothesis of globoid cell leukodystrophy pathology. Journal of Neuroscience Research, v. 94, n. 11, p. 1049-1061, 2016. ODRIOZOLA, E.; CAMPERO, C., LOPEZ, T.; MARIN, R.; CASARO, G.; ANDRADA, M. Neuropathological effects and deaths of cattle and sheep in Argentina from Phalaris angusta. Veterinary and Human Toxicology, v. 33, n. 5, p. 465-467, 1991. ODRIOZOLA, E.; ODEON, A.; CANTON, G.; CLEMENTE, G.; ESCANDE, A. Diplodia maydis: a cause of death of cattle in Argentina. New Zealand Veterinary Journal, v. 53, n. 2, p. 160-161, 2005. OGAWA, M.; UCHIDA, K.; ISOBE, K.; SAITO, M.; HARADA, T.; CHAMBERS, J. K.; NAKAYAMA, H. Globoid cell leukodystrophy (Krabbe's disease) in a Japanese domestic cat. Neuropathology, v. 34, n. 2, p. 190-196, 2014. OLIVEIRA JÚNIOR, C. A.; RIET-CORREA, F.; DUARTE, M. D.; CERQUEIRA, V. D.; ARAÚJO, C. V.; RIET-CORREA, G. Sinais clínicos, lesões e alterações produtivas e reprodutivas em caprinos intoxicados por Ipomoea carnea subsp. fistulosa (Convolvulaceae) que deixaram de ingerir a planta. Pesquisa Veterinária Brasileira, v. 31, n. 11, p. 953-960, 2011. OLIVEIRA JÚNIOR, C. A.; RIET-CORREA, G.; RIET-CORREA, F. Intoxicação por plantas que contêm swainsonina no Brasil. Ciência Rural, v. 43, n. 4, 2013. PAGANINI FILHO, W. S.; TIRAPELLI, A. C. N.; PEREIRA, T. G.; WOUTERS A. T. B.; WOUTERS, F. Intoxicação por Sida carpinifolia em ovinos. Encontro Nacional de Diagnóstico Veterinário, 28 jun.-3 jul., Campo Grande, MS. (Resumo). 2008. PALMANO, K.; ROWAN, A; GUILLERMO, R.; GUAN, J.; McJARROW, P. The role of gangliosides in neurodevelopment. Nutrients, v. 7, n. 5, p. 3891-3913, 2015. PAULOVICH, F. B.; PORTIANSKY, E. L.; GIMENO, E. J.; SCHILD, A. L.; MÉNDEZ, M. C.; RIET-CORREA, F. Lectin histochemical study of lipopigments present in the cerebellum of Solanum fastigiatum var. fastigiatum intoxicated cattle. Transboundary and Emerging Diseases, v. 49, n. 9, p. 473-477, 2002. PEDROSO, P. M. O.; PESCADOR, C. A.; OLIVEIRA, E. C.; SONNE, L.; BANDARRA, P. M.; RAYMUNDO, D. L.; DRIEMEIER, D. Intoxicações naturais por plantas em ruminantes diagnosticadas no Setor de Patologia Veterinária da UFRGS no período de 1996-2005. Acta Scientiae Veterinariae, v. 35, n. 2, p. 213-218, 2007. 69 PEDROSO, P. M. O.; OLIVEIRA, L. G. S.; CRUZ, C. E. F.; SOARES, M. P.; BARRETO, L. R. B.; DRIEMEIER, D. Doença do armazenamento lisossomal induzida pelo consumo de Sida carpinifolia em bovinos do Rio Grande do Sul. Pesquisa Veterinária Brasileira, v. 30, n. 10, p. 833-838, 2010. PEDROSO, P. M. O.; COLODEL, E. M.; SEITZ, A. L.; CORREA, G. L. F.; SOARES, M. P.; DRIEMEIER, D. Pathological findings in fetuses of goats and cattle poisoned by Sida carpinifolia (Malvaceae). Pesquisa Veterinária Brasileira, v. 32, n. 3, p. 227-230, 2012. PIMENTEL, L. A.; MAIA, L. A.; CAMPOS, E. M.; DANTAS, A. F. M.; MEDEIROS, R. M. T.; PFISTER, J. A.; COOK, D.; RIET-CORREA, F. Aversão alimentar condicionada no controle de surtos de intoxicações por Ipomoea carnea subsp. fistulosa e Turbina cordata em caprinos. Pesquisa Veterinária Brasileira, v. 32, n. 8, p. 707-714, 2012. PHILLIPS, N. C.; ROBINSON, D.; WINCHESTER, B. G.; JOLLY, R. D. Mannosidosis in Angus cattle. The enzymic defect. Biochemical Journal, v. 137, n. 2, p. 363-371, 1974. PIMENTEL, L. A.; MAIA, L. A.; CARVALHO, F. K. L.; CAMPOS, E. M.; PFISTER, J. A.; COOK, D.; MEDEIROS, R. M. T.; RIET-CORREA, F. Aversão alimentar. Aversão alimentar condicionada para o controle da intoxicação por Ipomoea carnea subsp. fistulosa em caprinos. Pesquisa Veterinária Brasileira, v. 33, n. 6, p. 719-723, 2013. PLATT, F. M.; NEISES, G. R.; REINKENSMEYER, G.; TOWNSEND, M. J.; PERRY, V. H.; PROIA, R. L.; WINCHESTER, B.; DWEK, R. A.; BUTTERS, T. D. Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin. Science, v. 276, n. 5311, p. 428-431, 1997. PLUMLEE, K. H.; GALEY, F. D. Neurotoxic mycotoxins: A review of fungal toxins that cause neurological disease in large animals. Journal of Veterinary Internal Medicine, v. 8, n. 1, p. 49-54, 1994. PRESTIDGE, R. A. Causes and control of perennial ryegrass staggers in New Zealand. Agriculture, Ecosystems & Environment, v. 44, n. 1-4, p. 283-300, 1993. PRITCHARD, D. H.; NAPTHINE, D. V.; SINCLAIR, A. J. Globoid cell leucodystrophy in polled Dorset sheep. Veterinary Pathology, v. 17, n. 4, p. 399-405, 1980. RALPHS, M. H.; PROVENZA, F. D. Conditioned food aversions: principles and practices, with special reference to social facilitation. Proceedings of the Nutrition Society, v. 58, n. 4, p. 813-820, 1999. RECH, R. R.; RISSI, D. R.; RODRIGUES, A.; PIEREZAN, F.; PIAZER, J. V. M.; KOMMERS, G. D.; BARROS, C. S. L. Intoxicação por Solanum fastigiatum (Solanaceae) em bovinos: históricos, sinais clínicos e morfometria das lesões cerebelares. Pesquisa Veterinária Brasileira, v. 26, p. 123-132, 2006. 70 REGO, R. O.; AFONSO, J. A. B.; MENDONÇA, C. L.; SOARES, G. S. L.; TORRES, M. B. A. M. Alterações no SNC e morfometria cerebelar de bovinos intoxicados experimentalmente por Solanum paniculatum. Pesquisa Veterinária Brasileira, v. 32, n. 11, p. 1107-1115, 2012. REINER, Ž.; GUARDAMAGNA, O., NAIR, D.; SORAN, H.; HOVINGH, K, BERTOLINI, S.; JONES, S.; CORIC, M.; CALANDRA S., HAMILTON, J.; EAGLETON, T.; EMILIO, R. Lysosomal acid lipase deficiency–an under-recognized cause of dyslipidaemia and liver dysfunction. Atherosclerosis, v. 235, n. 1, p. 21-30, 2014. RIET-CORREA, F.; SCHILD, A. L.; MÉNDEZ, M. C.; TAVARES, A. S.; RODRIGUES, J. Intoxicação por Claviceps paspali em bovinos no Rio Grande do Sul. Pesquisa Veterinária Brasileira, v. 3, n. 2, p. 59-65, 1983. RIET-CORREA, F.; SCHILD, A. L.; FERNANDES, C. G. Enfermidades do sistema nervoso dos ruminantes no sul do Rio Grande do Sul. Ciência Rural, v. 28, n. 2, p. 341-348, 1998. RIET-CORREA, F.; BARROS, S. S.; MÉNDEZ, M. C.; GEVEHR-FERNANDES, C.; PEREIRA NETO, O. A.; SOARES, M. P. McGAVIN, M. D. Axonal degeneration in sheep caused by the ingestion of Halimium brasiliense. Journal of veterinary diagnostic investigation, v. 21, n. 4, p. 478-486, 2009. RIET-CORREA, F. RIVERO, R.; ODRIOZOLA, E.; ADRIEN, M. L.; MEDEIROS, R. M. T.; SCHILD, A. L. Mycotoxicoses of ruminants and horses. Journal of Veterinary Diagnostic Investigation, v. 25, n. 6, p. 692-708, 2013. SANTOS, N. V. M.; SARKIS, J. E. S.; GUERRA, J. L.; MAIORKA, P. C.; HORTELANI, M. A.; SILVA, F. F.; ORTOLANI, E. L. Avaliação epidemiológica, clínica, anatomopatológica e etiológica de surtos de ataxia em cabritos e cordeiros. Ciência Rural, v. 36, n. 4, p. 1207-1213, 2006. SEITZ, A. L.; COLODEL, E. M.; BARROS, S. S.; DRIEMEIER, D. Experimental poisoning by Sida carpinifolia (Malvaceae) in sheep. Pesquisa Veterinária Brasileira, v. 25, n. 1, p. 15-20, 2005a. SEITZ, A. L.; COLODEL, E. M.; SCHMITZ, M.; GIMENO, E. J.; DRIEMEIER, D. Use of lectin histochemistry to diagnose Sida carpinifolia (Malvaceae) poisoning in sheep. Veterinary Record-English Edition, v. 156, n. 12, p. 386-388, 2005b. SCHULTHEISS, P. C.; GARDNER, S. A.; OWENS, J. M.; WENGER, D. A.; THRALL, M. A. Mucopolysaccharidosis VII in a cat. Veterinary Pathology, v. 37, n. 5, p. 502-505, 2000. SHULL, R. M.; MUNGER, R. J.; SPELLACY, E.; HALL, C. W.; CONSTANTOPOULOS, G.; NEUFELD, E. F. Canine alpha-L-iduronidase deficiency. A model of mucopolysaccharidosis I. The American Journal of Pathology, v. 109, n. 2, p. 244, 1982. 71 SIGURDSON, C. J.; BASARABA, R. J.; MAZZAFERRO, M.; GOULD, D. H. Globoid cell-like leukodystrophy in a domestic longhaired cat. Veterinary Pathology, v. 39, n. 4, p. 494-496, 2002. SIMÃO-BIANCHINI, R.; FERREIRA, P.P.A. Ipomoea in Lista de Espécies da Flora do Brasil. Jardim Botânico do Rio de Janeiro. Disponível em: <http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB7028>. Acesso em: 01 Ago. 2016. SOUSA, R. S.; IRIGOYEN, L. F. Intoxicação experimental por Phalaris angusta (Gramineae) em bovinos. Pesquisa Veterinária Brasileira, v. 19, n. 3/4, p. 116-122, 2014. STEGELMEIER, B. L.; MOLYNEUX, R. J.; ELBEIN, A. D.; JAMES, L. F. The lesions of locoweed (Astragalus mollissimus), swainsonine, and castanospermine in rats. Veterinary Pathology, v. 32, n. 3, p. 289-298, 1995. STEGELMEIER, B. L.; JAMES, L. F.; PANTER, K. E.GARDNER, D. L.; PFISTER, J. A.; RALPHS, M. H.; MOLYNEUX, R. J. Dose response of sheep poisoned with locoweed (Oxytropis sericea). Journal of Veterinary Diagnostic Investigation, v. 11, n. 5, p. 448-456, 1999. STEGELMEIER, B. L.; MOLYNEUX, R. J.; ASANO, N.; WATSON, A. A.; NASH, R. J. The comparative pathology of the glycosidase inhibitors swainsonine, castanospermine, and calystegines A3, B2, and C1 in mice. Toxicologic Pathology, v. 36, n. 5, p. 651-659, 2008. TAYLOR, R. M.; FARROW, B. R. H.; STEWART, G. J.; HEALY, P. J. Enzyme replacement in nervous tissue after allogeneic bone-marrow transplantation for fucosidosis in dogs. The Lancet, v. 328, n. 8510, p. 772-774, 1986. THOMPSON, J. N.; JONES, M. Z.; DAWSON, G.; HUFFMAN, P. S. N-acetylglucosamine 6-sulphatase deficiency in a Nubian goat: a model of Sanfilippo syndrome type D (mucopolysaccharidosis IIID). Journal of Inherited Metabolic Disease, v. 15, n. 5, p. 760-768, 1992. TOKARNIA, C. H.; BRITO, M. F.; BARBOSA, J. D.; PEIXOTO, P. V.; DOBEREINER, J. Deficiências minerais em animais de produção. Editora Helianthus, Rio de Janeiro, 2010. TOKARNIA, C. H.; BRITO, M. F.; BARBOSA, J. D.; PEIXOTO, P. V.; DOBEREINER, J. Plantas tóxicas do Brasil para animais de produção. Editora Helianthus, Rio de Janeiro, 2012. VALAYANNOPOULOS, V.; MENGEL, E.; BRASSIER, A; GRABOWSKY, G. Lysosomal acid lipase deficiency: Expanding differential diagnosis. Molecular Genetics and Metabolism, v. 120, n. 1, p. 62-66, 2017. VOGLER, C.; BIRKENMEIER, E. H.; SLY, W. S.; LEVY, B.; PEGORS, C.; KYLE, J. W.; BEAMER, W. G. A murine model of mucopolysaccharidosis VII. Gross and 72 microscopic findings in beta-glucuronidase-deficient mice. The American Journal of Pathology, v. 136, n. 1, p. 207, 1990. WALKLEY, S. U.; BLAKEMORE, W. F.; PURPURA, D. P. Alterations in neuron morphology in feline mannosidosis. Acta Neuropathologica, v. 53, n. 1, p. 75-79, 1981. WAKAKURI, H.; NAKAMURA, S.; UTSUMI, K.; SHIMIZU, W.; YASUTAKE, M. Novel α-Galactosidase A Mutation (K391E) in a Young Woman With Severe Cardiac and Renal Manifestations of Fabry Disease. International Heart Journal, v. 57, n. 5, p. 637-639, 2016. WHITFIELD, P.; JOHNSON, A. W.; DUNN, K. A.; DELAUCHE, A. J. N.; WINCHESTER, B. G.; FRANKLIN, R. J. M. GM1-gangliosidosis in a cross-bred dog confirmed by detection of GM1-ganglioside using electrospray ionisation-tandem mass spectrometry. Acta Neuropathologica, v. 100, n. 4, p. 409-414, 2000. WHITTEM, J. H.; WALKER, D. “Neuronopathy” and “pseudolipidosis” in Aberdeen‐Angus calves. The Journal of Pathology, v. 74, n. 2, p. 281-288, 1957. WHITTINGTON, R. J. SEARSON, J. E.; WHITTAKER, S. J.; GLASTONBURY, J. R. W. Blindness in goats following ingestion of Stypandra glauca. Australian Veterinary journal, v. 65, n. 6, p. 176-181, 1988. WILKERSON, M. J.; LEWIS, D. C.; MARKS, S. L.; PRIEUR, D. J. Clinical and morphologic features of mucopolysaccharidosis type II in a dog: naturally occurring model of Hunter syndrome. Veterinary Pathology, v. 35, n. 3, p. 230-233, 1998. WILLING, A. E.; GARBUZOVA-DAVIS, S. N.; ZAYKO, O.; DERASARI, H. M.; RAWLS, A. E.; JAMES, C. R.; SANBERG, P. R. Repeated administrations of human umbilical cord blood cells improve disease outcomes in a mouse model of Sanfilippo syndrome type III B. Cell Transplantation, v. 23, n. 12, p. 1613-1630, 2014. WINCHESTER, B.; VELLODI, A.; YOUNG, E. The molecular basis of lysosomal storage diseases and their treatment. Biochemical Society Transactions, v. 28, parte 2, p. 150-154, 2000. XU, M.; MOTABAR, O.; FERRER, M.; MARUGAN, J. J.; ZHENG, W.; OTTINGER, E. A. Disease models for the development of therapies for lysosomal storage diseases. Annals of the New York Academy of Sciences, v. 1371, n. 1, p. 15-29, 2016. YOGALINGAM, G.; POLLARD, T.; GLIDDON, B.; JOLLY, R. D.; HOPWOOD, J. J. Identification of a mutation causing mucopolysaccharidosis type IIIA in New Zealand Huntaway dogs. Genomics, v. 79, n. 2, p. 150-153, 2002. YUZIUK, J. A.; BERTONI, C.; BECCARI, T.; ORLACCHIO, A.; WU, Y.; LI, S.; LI, Y. Specificity of Mouse GM2 Activator Protein and β-N-Acetylhexosaminidases A and B - Similarities and differences with their human counterparts in the catabolism of GM2. Journal of Biological Chemistry, v. 273, n. 1, p. 66-72, 1998. 73 ZACHARY, J. F. Pathologic Basis of Veterinary Disease-E-Book. Elsevier Health Sciences, 6a ed. 1318p. 2016.por
dc.rightsAcesso Abertopor
dc.subjectArmazenamentopor
dc.subjectswainsoninapor
dc.subjectlectinaspor
dc.subjectStorageeng
dc.subjectswainsonineng
dc.subjectlectinseng
dc.subject.cnpqMedicina Veterináriapor
dc.titleDoença do armazenamento lisossomal induzida por Sida planicaulis Cav. (Malvaceae) em ovinos no Estado do Rio de Janeiropor
dc.title.alternativeLysosomal storage disease induced by Sida planicaulis Cav. (Malvaceae) in sheep in the state of Rio de Janeiroeng
dc.typeTesepor
Appears in Collections:Doutorado em Medicina Veterinária (Patologia e Ciências Clínicas)

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