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  4. Mestrado Multicêntrico em Ciências Fisiológicas
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dc.creatorAlmeida, Cláudio da Silva-
dc.creator.Latteshttp://lattes.cnpq.br/0560189477795224por
dc.contributor.advisor1Rocha, Fabio Fagundes da-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3804957959723162por
dc.contributor.referee1Sannago, Marcelo Felippe-
dc.contributor.referee2Reis, Luis Carlos-
dc.date.accessioned2020-06-02T13:53:15Z-
dc.date.issued2012-06-14-
dc.identifier.citationALMEIDA, Cláudio da Silva. Influência do enriquecimento ambiental na expressão comportamental e de C-fos em animais submetidos ao labirinto em cruz elevado. 2012. 38 f. Dissertação (Mestrado em Ciências Fisiológicas) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2012.por
dc.identifier.urihttps://tede.ufrrj.br/jspui/handle/jspui/3596-
dc.description.resumoO presente trabalho estudou os efeitos do enriquecimento ambiental (EA) na expressão comportamental de camundongos nos testes do labirinto em cruz elevado (LCE), campo aberto (CA) e suspensão pela cauda (SPC) além de avaliar a expressão de c-fos no encéfalo de camundongos submetidos ao LCE após exposição ao EA em diferentes fases da vida. Casais de camundongos foram colocados em dois ambientes, enriquecido ou padrão e os filhotes destes casais utilizados nos experimentos aos 70 dias de idade. No primeiro experimento, os filhotes foram mantidos no mesmo ambiente de criação dos pais, sendo divididos em três grupos: PD1 (controle, ambiente padrão por toda a vida), ENR-ADAPT (enriquecimento por toda a vida, adaptado às condições padrão por 1 semana antes dos testes), ENR-TOTAL (enriquecimento por toda a vida) que foram submetidos a uma bateria de testes comportamentais. Em um segundo experimento, foram estudados 4 grupos: ENR (enriquecimento a vida inteira), ENRP (enriquecimento até o desmame), PENR (enriquecimento após o desmame) e CON (controle, vivendo em ambiente padrão por toda a vida) que foram submetidos ao LCE e logo após realizada a imunohistoquímica para c-fos. No experimento 1, os grupos ENR-ADAPT e ENR-TOTAL apresentaram menor grau de ansiedade no LCE, caracterizado principalmente por maior % de tempo de permanência nos braços abertos. No CA, os grupos ENR-ADAPT e ENR-TOTAL apresentaram aumento das atividades motora e exploratória com aumento no número de quadrantes percorridos e levantamentos realizados. O protocolo utilizado não apresentou atividade do tipo antidepressiva no SPC. No experimento 2, todos os grupos submetidos ao EA demonstraram redução da ansiedade no LCE, caracterizada por aumento das % de tempo e entradas nos braços abertos. Na análise da expressão de c-fos não houve diferenças significativas na análise de c-fos dos grupos ENR, ENRP e PENR em relação ao grupo CON na substância cinzenta periaquedutal, córtex cingulado e nos núcleos medial, central e basolateral da amígdala. Assim o enriquecimento ambiental parece promover efeitos ansiolíticos quando implementado em qualquer fase da vida no teste do LCE, este efeito parece não estar correlacionado com alterações na atividade neuronal nas áreas analisadas.por
dc.description.abstractThe present work aimed to study the effects of environmental enrichment (EE) on the behavioral expression of mice in elevated plus maze (EPM), open field (OF) and tail suspension (TST) tests as well as evaluate the expression of c-fos in the brain of mice submitted to the EPM after exposure to EE in different stages of life. Pairs of mice were placed in two environments, enriched or standard and the offspring of these couples were used in the experiments at 70 days old. In the first experiment, the pups were kept in the same environment of them parents and were divided into three groups, PD1 (control, standard environment for all them life), ENR-ADAPT (enrichment for all them life but adapted to the standard conditions for 1 week before testing), ENR-TOTAL (enrichment for all them life) who underwent a battery of behavioral tests. In a second experiment, four groups were studied: ENR (enrichment lifetime), ENRP (enrichment up to weaning), PENR (enrichment after weaning) and CON (control, living in standard environment for al them life). These groups were exposed to the EPM and after that were used to perform the immunohistochemistry for c-fos. In experiment 1, the groups ENR-ADAPT and ENRTOTAL showed lower levels of anxiety in the EPM than PD1 group, characterized mainly by higher % of time spent in the open arms. In the OF, the groups ENR-ADAPT and ENRTOTAL showed an increase in motor and exploratory activities reflected by an increase in the number of quadrants crossed and rearings. Antidepressant properties was not characterized in the TST. In experiment 2, all groups submitted to the EE showed a reduction in the anxiety expressed in the EPM, characterized by increase in the % time and entries in the open arms. Considering the c-fos expression analysis, no significant differences in the analysis of c-fos between ENR, ENRP, PENR and the CON group in the periaqueductal gray matter, cingulate cortex, medial nucleus of the amygdala, basolateral nucleus of the amygdale and central nucleus of the amygdala. Thus, environmental enrichment seems to promote anxiolytic effects in the EPM test when implemented at any stage of life. This effect seems no to be correlated with a changes in neuronal activity in the areas analyzed.eng
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dc.description.sponsorshipFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJpor
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpor
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dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.publisher.departmentInstituto de Ciências Biológicas e da Saúdepor
dc.publisher.countryBrasilpor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicaspor
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dc.rightsAcesso Abertopor
dc.subjectneuroanatomia funcionalpor
dc.subjectativação neuronalpor
dc.subjectansiolíticopor
dc.subjectfunctional neuroanatomyeng
dc.subjectneuronal activationeng
dc.subjectanxiolyticeng
dc.subject.cnpqFisiologiapor
dc.titleInfluência do enriquecimento ambiental na expressão comportamental e de C-fos em animais submetidos ao labirinto em cruz elevadopor
dc.title.alternativeInfluence of environmental enrichment on behavioral and C-fos expression in animals submitted to the elevated plus-mazepor
dc.typeDissertaçãopor
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